Transcriptional control of inflammation
Acute and chronic diseases of inflammation are caused by uncontrolled activation of the immune system and by ineffective return to homeostasis following insult resolution. Environmental and genetic factors are contributing to immune dysregulation. On the genetic side, not only inter-individual variations are influencing the inflammatory responses, but also the epigenetic control of gene expression by transcription factors is important.
The aim of our lab is to understand the role of transcription factors in normal and pathological inflammatory responses. We use cutting-edge molecular biology and genomics methods to:
Investigate the functional impact of human genetic variations in autoimmune and chronic inflammatory diseases, with a focus on hypothyroidism and rheumatoid diseases
Identify and characterize the function of transcription factors in immune development and function, as well as epigenitic reprogramming
Develop innovative anti-inflammatory treatments, especially to target cerebral malaria
Proud Member of
McGill Genome
Centre
McGill Research Centre
on Complex Traits
McGill Interdisciplinary Initiative in Infection and Immunity
Quebec Cell, Tissue & Gene Therapy Network –ThéCell
OUR RESEARCH IS SUPPORTED by
