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"To get to know, to discover, to publish—this is the destiny of a scientist."

"Connaître, découvrir, communiquer—telle est, au fond, notre honorable destinée."

- François Arago, 1855 -

Lévy R, Gothe F, Momeni M, Magg T, Materna M, Peter P, Rädler J, Philippot Q, Rack-Hoch A, Langlais D, […], Abel L, Malissen B, Marr N, Klein C, Casanova JL, Hauck F, Béziat V (2023) Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency. J Exp Med. 220 (2): e20220275, PMID:

Douanne N, #Dong G, #Amin A, Bernardo L, Blanchette M, Langlais D, Olivier M, Fernandez-Prada C (2022) Leishmania parasites exchange drug-resistance genes through extracellular vesicles. Cell Reports. 40:111121

Fava VM, Bourgey M, Nawarathna PM, Orlova M, Cassart P, Vinh DC, Cheng MP, Bourque G, Schurr E*, Langlais D* (2022) A system biology approach identifies candidate drugs to reduce mortality in severely ill COVID-19 patients. Science Advances. 8(22):1-25. PMID: 35648852

Farge D, Loisel S, Resche-Rigon M, Lansiaux P, Colmegna I, Langlais D, [...], Wang HC, Michonneau D, Martinaud C, Sensebé L, Cras A, Tarte K (2022) Safety and preliminary efficacy of allogeneic bone marrow-derived multipotent mesenchymal stromal cells for systemic sclerosis: a single-centre, open-label, dose-escalation, proof-of-concept, phase 1/2 study. The Lancet Rheumatology. 4(2):E91-E104,

Ramendra R, Mancini M#, Ayala JM#, Tung LT, Isnard S, Lin J, Routy JP, Nijnik A, Langlais D* (2021) Glutathione metabolism is a regulator of the acute inflammatory response of monocytes to (1->3)-ꞵ-D-Glucan. Frontiers in Immunology. 12:694152, PMID: 34858388

Lévy R, Langlais D, Béziat V, Rapaport F, Rao G, Lazarov, Bourgey M, Zhou YR, Briand C, Moriya K, Ailal F, Avery D, Markle J, Lim AI, Ogishi M, Yang R, Pelham S, Emam M, Migaud M, […], Liu K, Gros P, Geissmann F, Tangye S, Casanova JL, Puel A. (2021) Inherited human c-Rel deficiency disrupts adaptive immunity. Journal of Clinical Investigations. 131(17):e150143, PMID: 34623332

Ogishi M, Yang R, Aytekin C, Langlais D, Bourgey M, Khan T, Ali F, Rahman M, Delmonte O, […], Abel L, Bogunovic D, Marr N, Notarangelo LD, Tangye SG, Honjo T, Gros P, Boisson-Dupuis S, Casanova JL (2021) Inherited human PD-1 deficiency underlies tuberculosis and autoimmunity. Nature Medicine. doi: 10.1038/s41591-021-01388-5. PMID: 34183838

Lin YH, Liang Y, Wang HC, Tung LT, Förster M, Subramani PG, Di Noia JM, Clare S, Langlais D, Nijnik A (2021) Regulation of B lymphocyte development by histone H2A deubiquitinase BAP1. Frontiers in Immunology. (IF=6.4) 12:e626418. PMID: 33912157

Mancini M, Charbonneau B, Langlais D, Vidal SM (2021) The c-Rel transcription factor limits early interferon and neuroinflammatory responses to prevent herpes simplex encephalitis onset in mice. Scientific Reports (IF=5.1) 11:21171, PMID: 34707143

Yang R, #Mele F, #Worley L, #Langlais D, #Rosain J, […], Bourgey M, [...], Tangye S, Sallusto F, Bustamante J, Casanova JL (2020) Human T-bet governs innate and innate-like IFN-γ immunity against mycobacteria. Cell. 183(7):1826-1847.e31. PMID: 33296702

Belle JI, Wang HC, Fiore A, Petrov JC, Lin YH, Feng C, Nguyen TTM, Behrends U, Campeau PM, Brunet T, Leszinski GS, Gros P, Langlais D*, Nijnik A* (2020) MYSM1 Maintains Ribosomal Protein Gene Expression in Hematopoietic Stem Cells to Prevent Hematopoietic Dysfunction. JCI Insight. Epub May 2020, 5(13):e125690.  PMID: 32641579

Kennedy JM, Bassenden A, Vidal SM, Berghuis AM, Taniuchi I, Behr, MA, #Langlais D, #Gros P* (2020) Zbtb7b is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis. Infection and Immunity. Epud Nov 2019.  PMID: 31792077

Kong XF, Martinez-Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick E, Ma CS, Breton G, Lucero KB, Langlais D, [...], Abel L, Boisson-Dupuis S, Schröder B, Nussenzweig MC, Liu K, Geissmann F, Tangye SG, Gros P, Sallusto F, Bustamante J, Casanova JL. (2018) Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nature Immunol. Epub Aug 2018.  PMID: 30127434

#Torre S, #Langlais D, Gros P. (2018) Genetic Analysis of Severe Malaria in the Mouse Model of Infection with Plasmodium berghei. Mammalian Genome. Review article. Epub Jun 2018.  PMID: 29922917

Langlais D*, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandal I, Tarry MJ, Schmeing M, Kain KC, Porco JA Jr, Pelletier J, Gros P*. (2018) Rocaglates as dual-targeting agents for experimental cerebral malaria. PNAS, Epub Feb 2018, 115(10):E2366–E2375  PMID: 29463745

#Langlais D, #Fodil N, Gros P (2017) Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies. Ann. Rev. Immunol. Epub Dec 2016, 35:1-30.  PMID: 27912315

Torre S, Polyak M, Langlais D, Fodil N, Kennedy J, Radovanovic I, Berghout J, Lathrop M, Vidal S, Gros P. (2017) USP15 regulates type I interferon response in vivo and is required for pathogenesis in microbial and autoimmune models of neuroinflammation. Nature Immunol. Epub Oct 2016, 18:54–63.  PMID: 27721430

Langlais D, Barreiro L, Gros P. (2016) The macrophage IRF8-IRF1 regulome is required for protection against infections, and is associated with chronic inflammation. J Exp Med. 213(4):585-603.  PMID: 27001747

#Berghout J, #Langlais D, Radovanovic I, Tam M, MacMicking JD, Stevenson MM, Gros P. (2013) Irf8-Regulated Genomic Responses Drive Pathological Inflammation during Cerebral Malaria. PLOS Pathogens. 9(7): e1003491.  PMID: 23853600

Langlais D, Couture C, Balsalobre A, Drouin J. (2012) The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome. Molecular Cell. 47(1):38-49.  PMID: 22633955

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