SELECTED PUBLICATIONS
"To get to know, to discover, to publish—this is the destiny of a scientist."
"Connaître, découvrir, communiquer—telle est, au fond, notre honorable destinée."
- François Arago, 1855 -
Amin AB, Ibarra Meneses AV, Gagnon S, Merhi G, Olivier M, Ndao M, Blanchette M, Fernandez-Prada C, Langlais D*. (2025) Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi. In review
BioRxiv preprint: https://doi.org/10.1101/2025.07.18.665644
Tung LZ, Jiang RR, Pozzebon B, Mancini M, Droin L, Yousefi M, Kim JE, Mousa M, Liang Y, Colmegna I, Malo D, Langlais D*, Vidal SM*, Nijnik A* (2025) Trained Immunity Affecting Dendritic Cell Differentiation and Function in Rheumatoid Arthritis. In review
BioRxiv preprint: https://doi.org/10.1101/2025.02.28.640673
Brilland B, Despré M, Khatri R, Quemeneur T, Vandenbussche C, Merillon N, Boizard-Moracchini A, Roy M, Preisser L, Riou J, Piccoli GB, Djema A, Henry N, Blanchet O, Bonn S, Berthier CC, Grayson P, Delneste Y, Gnemmi V, Blanco P, Copin MC, Langlais D, Augusto JF, the Maine-Anjou Registry Research Group (2025) A stronger type I interferon signature distinguishes ANCA-associated vasculitis phenotypes and predicts kidney prognosis. Kidney International. In press. https://doi.org/10.1016/j.kint.2025.07.034
Brilland B, Riou J, Quemeneur T, Vandenbussche C, Merillon N, Boizard-Moracchini A, Roy M, Despré M, Piccoli GB, Djema A, Henry N, Preisser L, Blanchet O, Gnemmi V, Copin MC, Langlais D, Jeannin P, Blanco P, Delneste Y, Augusto JF, the Maine-Anjou Registry Research Group (2025) Identification of renal transcripts associated with kidney function and prognosis in ANCA-associated vasculitis. Journal of the American Society of Nephrology. In press, https://doi.org/10.1681/ASN.0000000779
Mai LT, Swaminathan S, Nguyen TH, Collette E, Charpentier T, Carmona-Pérez L, Loucif H, Lamarre A, Heinonen KM, Langlais D, Fritz JH, Stäger S (2025) The transcription factor IRF-5 is an essential metabolic checkpoint in CD8 T cells during chronic infection. EMBO J 44:4280 – 4300, doi.org/10.1038/s44318-025-00485-2
Ogishi M, Kitaoka K, Good-Jacobson KL, Rinchai D, Zhang B, Wang J, Gies V, Rao G, Nguyen T, Avery DT, Khan T, Smithmyer ME, Mackie J, Yang R, Arias AA,Asano T, Ponsin K, Chaldebas M, Zhang P, Peel JN, Bohlen J, Lévy R, Pelham SJ, Lei WT, Han JE, Fagniez I, Chrabieh M, Laine C, Langlais D, Gruber C, [...], Bogunovic D, Gros P, Marr N, Speake C, Oram RA, Béziat V, Bustamante J, Abel L, Boisson B, Korganow AS, Ma CS, Johnson MB, Chamoto K, Boisson-Dupuis S, Honjo T, Casanova JL, Tangye SG (2024) Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling. Immunity. 52(12): p2790-2807.e15. https://doi.org/10.1016/j.immuni.2024.10.014
Brizio M, Mancini M, Lora M, Joy S, Zhu S, Brilland B, Reinhardt DP, Farge D, Langlais D, Colmegna I (2024) Cytokine Priming Enhances the Antifibrotic Effects of Human Adipose Derived Mesenchymal Stromal Cells Conditioned Medium. Stem Cell Research & Therapy. 15:329 https://doi.org/10.1186/s13287-024-03916-9
Kulle A, Li Z, Kwak A, Mancini M, Young D, Groleau M, Avizonis DZ, Baglole CJ, Behr M, King IL, Divangahi M, Langlais D, Wang J, Blagih J, Penz E, Dufour A, Thanabalasuriar A (2024) Alveolar macrophage function is impaired following inhalation of berry e-cigarette vapour. PNAS. 121 (40) e2406294121, https://doi.org/10.1073/pnas.2406294121
Momenilandi M, Lévy R, Lagresle C, Li J, Esmaeilzadeh H, Fayand A, Guérin A, Mina ED, Rinchai D, Shearer D, Delmonte O, Yatim A, Le Floc’h C, Sobrino S, Mancini M, Neehus AL, Balogh K, [...], Boisson-Dupuis S, Bustamante J, Notarangelo L, Christensen N, Landegren N, Abel L, Marr N, Langlais D, Waterboer T, Ma CS, Tangye SG, Meyts I, Lachmann N, Hu J, Shahrooei M, Bossuyt X, Casanova JL, Béziat V (2024) FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice. Cell. 187, 1-21, doi.org/10.1016/j.cell.2024.04.009
Guérin A, Moncada-Vélez M, Jackson K, Ogishi M, Rosain J, Mancini M, Langlais D, Nunez A, [...], Abel L, Boisson-Dupuis S, Reis J, Marinho A, Lisco A, Farias E, Goodnow CC, Vasconcelos J, Béziat V, Ma CS, Somech R, Casanova JL, Bustamante J, Franco JL, Tangye SG (2024) Helper T cell immunity in humans with inherited CD4 deficiency. J Exp Med 221 (5): e20231044, doi.org/10.1084/jem.20231044
Materna M, Delmonte O #, Bosticardo M #, Momenilandi M #, Peyton CE £, Charmeteau-De Muylder B £, Bellworthy R £, Cederholm A £, Staels F £, Schramm CA £, Sayed S £, Le Floc’h C £, Ogishi M £, Rinchai D £, Guenoun A £, Bolze A £, Khan T £, Gervais A £, [...], Cheynier R $, Langlais D $, Landegren N $, Marr N $, Morio T *, Shahrooei M *, Schrijvers R *, Henrickson S *, Luche H*, Notarangelo L *, Casanova JL *, Béziat V * (2024) Functional ⍺β T cells and late-onset immunological conditions in humans with rare or common inherited Pre-TCR-⍺ deficiency. Science 383:6686, 66-86, doi:10.1126/science.adh4059 [#, £, $, * = Equal contributions]
Liang Y, Wang HC, Desivo NS, Seija N, Lin YS, Tung LZ, Di Noia JM, Langlais D, Nijnik A (2024) B-cell Intrinsic Regulation of Antibody Mediated Immunity by Histone H2A Deubiquitinase BAP1. Front Immunol. 15:2024, doi.org/10.3389/fimmu.2024.1353138
Mousa M, Liang Y, Tung LZ, Wang HC, Langlais D, Krawczyk C, Nijnik A (2024) Chromatin-binding deubiquitinase MYSM1 acts in hematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation. Immunology. 2024;1–18, doi.org/10.1111/imm.13758
† Olivier JF, † Langlais D, Jeyakumar T, Polyak MJ, Galarneau L, Cayrol R, Jiang H, Molloy KR, Xu G, Suzuki H, LaCava J, Gros P, Fodil N. (2024) Ccdc88b interacts with Rasal3 and Arhgef2 to regulate dendritic cells function in neuroinflammation and colitis. Communications Biology. 7:77, doi.org/10.1038/s42003-023-05751-9
† Co-first authors
Al-Aubodah TA, Aoudjit L, Pascale G, Perinpanayagam MA, Langlais D, Bitzan M, Samuel SM, Piccirillo CA, Takano T (2023) The extrafollicular B cell response is a hallmark of childhood idiopathic nephrotic syndrome. Nature Communications. 14:7682, doi.org/10.1038/s41467-023-43504-8
†Ibarra-Meneses AV, †Amin A, †Dong G, Olivier M *, Langlais D *, Fernandez-Prada C * (2023) Identification and Analysis of the DNA Content of Small Extracellular Vesicles Isolated from Leishmania Parasites. STAR Protocols. 4(2): 102248, doi.org/10.1016/j.xpro.2023.102248
* Corresponding and co-senior authors, † Co-first authors
Rosain J, Neehus AL, Manry J, Yang R, Tahuil N, Türel Ö, Bourgey M, Ogishi M, Doisne JM, Le Voyer T, Guérin A, Bastard P, Izquierdo HM, Moncada-Velez M, Han JE, Khan T, Rapaport F, Liu Z, Chan YH, Hong SH, Cheung A, Haake K, Mindt BC, Perez L, Zhang P, Al Ali F, Ata MMA, Rahman M, Kendir Y, Mancini M, [...], Marr Nico, Abel L, Tangye SG, Di Santo JP, Zhang Q, Zhang SY, Béziat V, Lachmann N, Langlais D, Casanova JL, Gros P, Bustamante J. (2023) Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria. Cell 186:621-645, doi.org/10.1016/j.cell.2022.12.038
Lévy R, Gothe F, Momeni M, Magg T, Materna M, Peter P, Rädler J, Philippot Q, Rack-Hoch A, Langlais D, […], Abel L, Malissen B, Marr N, Klein C, Casanova JL, Hauck F, Béziat V (2023) Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency. J Exp Med. 220 (2): e20220275, doi.org/10.1084/jem.20220275
Douanne N, #Dong G, #Amin A, Bernardo L, Blanchette M, Langlais D, Olivier M, Fernandez-Prada C (2022) Leishmania parasites exchange drug-resistance genes through extracellular vesicles. Cell Reports. 40:111121, doi.org/10.1016/j.celrep.2022.111121
Fava VM, Bourgey M, Nawarathna PM, Orlova M, Cassart P, Vinh DC, Cheng MP, Bourque G, Schurr E*, Langlais D* (2022) A system biology approach identifies candidate drugs to reduce mortality in severely ill COVID-19 patients. Science Advances. 8(22):1-25. PMID: 35648852
Farge D, Loisel S, Resche-Rigon M, Lansiaux P, Colmegna I, Langlais D, [...], Wang HC, Michonneau D, Martinaud C, Sensebé L, Cras A, Tarte K (2022) Safety and preliminary efficacy of allogeneic bone marrow-derived multipotent mesenchymal stromal cells for systemic sclerosis: a single-centre, open-label, dose-escalation, proof-of-concept, phase 1/2 study. The Lancet Rheumatology. 4(2):E91-E104, doi.org/10.1016/S2665-9913(21)00326-X
Ramendra R, Mancini M#, Ayala JM#, Tung LT, Isnard S, Lin J, Routy JP, Nijnik A, Langlais D* (2021) Glutathione metabolism is a regulator of the acute inflammatory response of monocytes to (1->3)-ꞵ-D-Glucan. Frontiers in Immunology. 12:694152, doi.org/10.3389/fimmu.2021.694152. PMID: 34858388
Lévy R, Langlais D, Béziat V, Rapaport F, Rao G, Lazarov, Bourgey M, Zhou YR, Briand C, Moriya K, Ailal F, Avery D, Markle J, Lim AI, Ogishi M, Yang R, Pelham S, Emam M, Migaud M, […], Liu K, Gros P, Geissmann F, Tangye S, Casanova JL, Puel A. (2021) Inherited human c-Rel deficiency disrupts adaptive immunity. Journal of Clinical Investigations. 131(17):e150143, doi.org/10.1172/JCI150143. PMID: 34623332
Ogishi M, Yang R, Aytekin C, Langlais D, Bourgey M, Khan T, Ali F, Rahman M, Delmonte O, […], Abel L, Bogunovic D, Marr N, Notarangelo LD, Tangye SG, Honjo T, Gros P, Boisson-Dupuis S, Casanova JL (2021) Inherited human PD-1 deficiency underlies tuberculosis and autoimmunity. Nature Medicine. doi: 10.1038/s41591-021-01388-5. PMID: 34183838
Lin YH, Liang Y, Wang HC, Tung LT, Förster M, Subramani PG, Di Noia JM, Clare S, Langlais D, Nijnik A (2021) Regulation of B lymphocyte development by histone H2A deubiquitinase BAP1. Frontiers in Immunology. (IF=6.4) 12:e626418. PMID: 33912157
Mancini M, Charbonneau B, Langlais D, Vidal SM (2021) The c-Rel transcription factor limits early interferon and neuroinflammatory responses to prevent herpes simplex encephalitis onset in mice. Scientific Reports (IF=5.1) 11:21171, PMID: 34707143
Yang R, #Mele F, #Worley L, #Langlais D, #Rosain J, […], Bourgey M, [...], Tangye S, Sallusto F, Bustamante J, Casanova JL (2020) Human T-bet governs innate and innate-like IFN-γ immunity against mycobacteria. Cell. 183(7):1826-1847.e31. PMID: 33296702
Belle JI, Wang HC, Fiore A, Petrov JC, Lin YH, Feng C, Nguyen TTM, Behrends U, Campeau PM, Brunet T, Leszinski GS, Gros P, Langlais D*, Nijnik A* (2020) MYSM1 Maintains Ribosomal Protein Gene Expression in Hematopoietic Stem Cells to Prevent Hematopoietic Dysfunction. JCI Insight. Epub May 2020, 5(13):e125690. PMID: 32641579
Kennedy JM, Bassenden A, Vidal SM, Berghuis AM, Taniuchi I, Behr, MA, #Langlais D, #Gros P* (2020) Zbtb7b is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis. Infection and Immunity. Epud Nov 2019. PMID: 31792077
Kong XF, Martinez-Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick E, Ma CS, Breton G, Lucero KB, Langlais D, [...], Abel L, Boisson-Dupuis S, Schröder B, Nussenzweig MC, Liu K, Geissmann F, Tangye SG, Gros P, Sallusto F, Bustamante J, Casanova JL. (2018) Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nature Immunol. Epub Aug 2018. PMID: 30127434
#Torre S, #Langlais D, Gros P. (2018) Genetic Analysis of Severe Malaria in the Mouse Model of Infection with Plasmodium berghei. Mammalian Genome. Review article. Epub Jun 2018. PMID: 29922917
Langlais D*, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandal I, Tarry MJ, Schmeing M, Kain KC, Porco JA Jr, Pelletier J, Gros P*. (2018) Rocaglates as dual-targeting agents for experimental cerebral malaria. PNAS, Epub Feb 2018, 115(10):E2366–E2375 PMID: 29463745
#Langlais D, #Fodil N, Gros P (2017) Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies. Ann. Rev. Immunol. Epub Dec 2016, 35:1-30. PMID: 27912315
Torre S, Polyak M, Langlais D, Fodil N, Kennedy J, Radovanovic I, Berghout J, Lathrop M, Vidal S, Gros P. (2017) USP15 regulates type I interferon response in vivo and is required for pathogenesis in microbial and autoimmune models of neuroinflammation. Nature Immunol. Epub Oct 2016, 18:54–63. PMID: 27721430
Langlais D, Barreiro L, Gros P. (2016) The macrophage IRF8-IRF1 regulome is required for protection against infections, and is associated with chronic inflammation. J Exp Med. 213(4):585-603. PMID: 27001747
#Berghout J, #Langlais D, Radovanovic I, Tam M, MacMicking JD, Stevenson MM, Gros P. (2013) Irf8-Regulated Genomic Responses Drive Pathological Inflammation during Cerebral Malaria. PLOS Pathogens. 9(7): e1003491. PMID: 23853600
Langlais D, Couture C, Balsalobre A, Drouin J. (2012) The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome. Molecular Cell. 47(1):38-49. PMID: 22633955