"To get to know, to discover, to publish—this is the destiny of a scientist."

"Connaître, découvrir, communiquer—telle est, au fond, notre honorable destinée."

- François Arago, 1855 -

Yang R, #Mele F, #Worley L, #Langlais D, #Rosain J, […], Bourgey M, [...], Tangye S, Sallusto F, Bustamante J, Casanova JL (2020) Human T-bet governs innate and innate-like IFN-γ immunity against mycobacteria. Cell. 183(7):1826-1847.e31. PMID: 33296702

Belle JI, Wang HC, Fiore A, Petrov JC, Lin YH, Feng C, Nguyen TTM, Behrends U, Campeau PM, Brunet T, Leszinski GS, Gros P, Langlais D*, Nijnik A* (2020) MYSM1 Maintains Ribosomal Protein Gene Expression in Hematopoietic Stem Cells to Prevent Hematopoietic Dysfunction. JCI Insight. Epub May 2020, 5(13):e125690.  PMID: 32641579

Kennedy JM, Bassenden A, Vidal SM, Berghuis AM, Taniuchi I, Behr, MA, #Langlais D, #Gros P* (2020) Zbtb7b is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis. Infection and Immunity. Epud Nov 2019.  PMID: 31792077

Kong XF, Martinez-Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick E, Ma CS, Breton G, Lucero KB, Langlais D, [...], Abel L, Boisson-Dupuis S, Schröder B, Nussenzweig MC, Liu K, Geissmann F, Tangye SG, Gros P, Sallusto F, Bustamante J, Casanova JL. (2018) Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nature Immunol. Epub Aug 2018.  PMID: 30127434

#Torre S, #Langlais D, Gros P. (2018) Genetic Analysis of Severe Malaria in the Mouse Model of Infection with Plasmodium berghei. Mammalian Genome. Review article. Epub Jun 2018.  PMID: 29922917

Langlais D*, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandal I, Tarry MJ, Schmeing M, Kain KC, Porco JA Jr, Pelletier J, Gros P*. (2018) Rocaglates as dual-targeting agents for experimental cerebral malaria. PNAS, Epub Feb 2018, 115(10):E2366–E2375  PMID: 29463745

#Langlais D, #Fodil N, Gros P (2017) Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies. Ann. Rev. Immunol. Epub Dec 2016, 35:1-30.  PMID: 27912315

Torre S, Polyak M, Langlais D, Fodil N, Kennedy J, Radovanovic I, Berghout J, Lathrop M, Vidal S, Gros P. (2017) USP15 regulates type I interferon response in vivo and is required for pathogenesis in microbial and autoimmune models of neuroinflammation. Nature Immunol. Epub Oct 2016, 18:54–63.  PMID: 27721430

Langlais D, Barreiro L, Gros P. (2016) The macrophage IRF8-IRF1 regulome is required for protection against infections, and is associated with chronic inflammation. J Exp Med. 213(4):585-603.  PMID: 27001747

#Berghout J, #Langlais D, Radovanovic I, Tam M, MacMicking JD, Stevenson MM, Gros P. (2013) Irf8-Regulated Genomic Responses Drive Pathological Inflammation during Cerebral Malaria. PLOS Pathogens. 9(7): e1003491.  PMID: 23853600

Langlais D, Couture C, Balsalobre A, Drouin J. (2012) The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome. Molecular Cell. 47(1):38-49.  PMID: 22633955