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Tree-man syndrome explained. The causes? CD28 deficiency!

Our latest contribution to Cell:

Another inborn error of immunity explained by Jean-Laurent Casanova's lab and colleagues.

The study of three patients with inherited CD28 deficiency, one of them having the "tree-man syndrome", reveals a narrow susceptibility to severe cutaneous HPV infection. The fact that the patients were otherwise healthy highlights the redundancy for signal 2 in T cell activation and protective immunity.

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