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SPPL2a: a new player in defenses against mycobacterial infections

Updated: Aug 23, 2018

We are happy to have participated in this huge team effort led by Dr Jean-Laurent Casanova at Rockefeller University. This work published in Nature Immunology (https://www.nature.com/articles/s41590-018-0178-z) identifies a new gene causing Mendelian Susceptibility to Mycobacterial Disease (MSMD). It describes how autosomal recessive SPPL2a deficiency (in human and mouse) impairs Th1* response to mycobacterial infections, such as BCG and tuberculosis.

The article was featured in an excellent News & Views by Sergio D. Rosenzweig

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Inflammation Genomics

McGill University Genome Center
McGill Research Centre on Complex Traits

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© 2018 by David Langlais