SPPL2a: a new player in defenses against mycobacterial infections
Updated: Aug 23, 2018
We are happy to have participated in this huge team effort led by Dr Jean-Laurent Casanova at Rockefeller University. This work published in Nature Immunology (https://www.nature.com/articles/s41590-018-0178-z) identifies a new gene causing Mendelian Susceptibility to Mycobacterial Disease (MSMD). It describes how autosomal recessive SPPL2a deficiency (in human and mouse) impairs Th1* response to mycobacterial infections, such as BCG and tuberculosis.