Using a system biology approach (scRNA + WGBS + ATACseq), we characterized the epigenomics modifications in severely ill COVID-19 patients based on their outcome: survival or decease. This highlighted key molecular pathways upregulated already at the time of ICU admission, in patients that will succumb from the infection. We propose candidate drugs that could reduce mortality in patient admitted to the ICU.
Thank you Vinicius Fava, Mathieu Bourgey, Pubudu Nawarathna, Pauline Cassart, Don Vinh, Marianna Orlova, Mathieu Cheng, Guillaume Bourque and Erwin Schurr for the great collaboration!
